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Cnidium lactone prevents bone loss in an ovariectomized rat model through the estrogen-alpha/BMP-2/Smad signaling pathway.
Wang Z, Bao HW, Xu YJ. Wang Z, et al. J Gene Med. 2020 Aug;22(8):e3198. doi: 10.1002/jgm.3198. Epub 2020 Apr 27. J Gene Med. 2020. PMID: 32267602
Moreover, western blot analyses were also performed to evaluate the effect of cnidium lactone on the ERalpha/BMP-2/Smad signaling pathway. RESULTS: Cnidium lactone treatment was associated with an increase in the BMD of the distal femur compared to tha …
Moreover, western blot analyses were also performed to evaluate the effect of cnidium lactone on the ERalpha/BMP-2/Smad signal …
Cnidium lactone stimulates osteogenic differentiation of bone marrow mesenchymal stem cells via BMP-2/smad-signaling cascades mediated by estrogen receptor.
Wang Z, Bao HW. Wang Z, et al. Am J Transl Res. 2019 Aug 15;11(8):4984-4991. eCollection 2019. Am J Transl Res. 2019. PMID: 31497215 Free PMC article.
Our aim was to study the osteogenic effect of cnidium lactone for bone marrow mesenchymal stem cells (BMSCs) and its potential mechanism. ...Cell Counting Kit-8 (CCK-8) was used to identify the optimal concentration of cnidium lactone. Alkaline Phospha …
Our aim was to study the osteogenic effect of cnidium lactone for bone marrow mesenchymal stem cells (BMSCs) and its potential …
The efficacy and potential mechanism of cnidium lactone to inhibit osteoclast differentiation.
Liang JY, Wu WL, Chen YX, Liu H. Liang JY, et al. Artif Cells Nanomed Biotechnol. 2019 Dec;47(1):3087-3093. doi: 10.1080/21691401.2019.1637881. Artif Cells Nanomed Biotechnol. 2019. PMID: 31343277
Cnidium lactone treatment considerably reduced RANKL-induced p38 MAPK and PI3K-Akt signal activity in RAW264.7 cells. ...Furthermore, cnidium lactone inhibited the expression of c-Fos and NFATc-1 with dose-dependently and enhanced by SB203580 and LY294 …
Cnidium lactone treatment considerably reduced RANKL-induced p38 MAPK and PI3K-Akt signal activity in RAW264.7 cells. ...Furth …
Effect of Cnidium Lactone on Serum Mutant P53 and BCL-2/BAX Expression in Human Prostate Cancer Cells PC-3 Tumor-Bearing BALB/C Nude Mouse Model.
Bi D, Yang M, Zhao X, Huang S. Bi D, et al. Med Sci Monit. 2015 Aug 18;21:2421-7. doi: 10.12659/MSM.893745. Med Sci Monit. 2015. PMID: 26286430 Free PMC article.
BACKGROUND: Cnidium lactone is a natural coumarin compound that can inhibit a variety of cancer cell proliferation and induce cancer cell apoptosis. ...AMACR and BAX levels showed no significant difference in the cnidium lactone group or the cyclophosp …
BACKGROUND: Cnidium lactone is a natural coumarin compound that can inhibit a variety of cancer cell proliferation and induce …
Covalent Modification of Proteins by Osthole Reactive Metabolites using Proteomic Approaches.
Zhuo Y, Chen H, Liu C, Zhang Y, Fang J, Li M, Wang Z, Jiang Q, Yu L, Pan H, Wang Q. Zhuo Y, et al. Curr Drug Metab. 2023;24(8):611-620. doi: 10.2174/1389200224666230727123006. Curr Drug Metab. 2023. PMID: 37519003
BACKGROUND: Osthole (OST) is a bioactive natural coumarin derived from the plant Cnidium monnieri (L.) Cusson fruit (She Chuang Zi), which has various pharmacological and biological activities. OST contains an alpha,beta- unsaturated lactone, which is an electrophil …
BACKGROUND: Osthole (OST) is a bioactive natural coumarin derived from the plant Cnidium monnieri (L.) Cusson fruit (She Chuang Zi), …
Optimization of Osthole in the Lactone Ring: Structural Elucidation, Pesticidal Activities, and Control Efficiency of Osthole Ester Derivatives.
Li S, Lv M, Sun Z, Hao M, Xu H. Li S, et al. J Agric Food Chem. 2021 Jun 16;69(23):6465-6474. doi: 10.1021/acs.jafc.1c01434. Epub 2021 Jun 2. J Agric Food Chem. 2021. PMID: 34077224
Here, we prepared a series of novel osthole-type ester derivatives modified in the lactone ring of osthole, which is isolated from Cnidium monnieri. The positions of H-3 and H-4 of the representative compound 4z were determined by a (1)H-(1)H COSY spectrum. By openi …
Here, we prepared a series of novel osthole-type ester derivatives modified in the lactone ring of osthole, which is isolated from …
Acaricidal and repellent effects of Cnidium officinale-derived material against Dermanyssus gallinae (Acari: Dermanyssidae).
Kim HK, Lee SJ, Hwang BY, Yoon JU, Kim GH. Kim HK, et al. Exp Appl Acarol. 2018 Apr;74(4):403-414. doi: 10.1007/s10493-018-0249-8. Epub 2018 Mar 22. Exp Appl Acarol. 2018. PMID: 29569074
The acaricidal activity of a methanolic extract and fractions from the rhizome of Cnidium officinale against Dermanyssus gallinae adults was investigated. ...
The acaricidal activity of a methanolic extract and fractions from the rhizome of Cnidium officinale against Dermanyssus gallinae adu …
Chemical structure-activity of cnidium rhizome-derived phthalides for the competence inhibition of proliferation in primary cultures of mouse aorta smooth muscle cells.
Kobayashi S, Mimura Y, Naitoh T, Kimura I, Kimura M. Kobayashi S, et al. Jpn J Pharmacol. 1993 Nov;63(3):353-9. doi: 10.1254/jjp.63.353. Jpn J Pharmacol. 1993. PMID: 8107327 Free article.
Inhibitory effects of cnidium rhizome-derived phthalides on competence and progression phases of fetal bovine serum (10%)-induced proliferation were compared in primary cultures of mouse aorta smooth muscle cells (SMC). ...Senkyunolide H in cnidium rhizome may be a …
Inhibitory effects of cnidium rhizome-derived phthalides on competence and progression phases of fetal bovine serum (10%)-induced pro …
Larvicidal and adulticidal activity of alkylphthalide derivatives from rhizome of Cnidium officinale against Drosophila melanogaster.
Tsukamoto T, Ishikawa Y, Miyazawa M. Tsukamoto T, et al. J Agric Food Chem. 2005 Jul 13;53(14):5549-53. doi: 10.1021/jf050110v. J Agric Food Chem. 2005. PMID: 15998112
The insecticidal activity of the chloroform extract of Cnidium officinale rhizomes and its constituents was investigated against larvae and adults of Drosophila melanogaster and compared with that of rotenone. ...Structure-activity relationships of phthalides isolated sugg …
The insecticidal activity of the chloroform extract of Cnidium officinale rhizomes and its constituents was investigated against larv …
Systems pharmacology approach uncovers Ligustilide attenuates experimental colitis in mice by inhibiting PPARγ-mediated inflammation pathways.
Huang Y, Zhang Y, Wan T, Mei Y, Wang Z, Xue J, Luo Y, Li M, Fang S, Pan H, Wang Q, Fang J. Huang Y, et al. Cell Biol Toxicol. 2021 Feb;37(1):113-128. doi: 10.1007/s10565-020-09563-z. Epub 2020 Oct 31. Cell Biol Toxicol. 2021. PMID: 33130971
Our in silico approach found that Ligustilide (LIG), one of the major active components of Angelica acutiloba and Cnidium Officinale, potently attenuated IBD. The following in vivo and in vitro results demonstrated that LIG prevented experimental mice colitis induced by de …
Our in silico approach found that Ligustilide (LIG), one of the major active components of Angelica acutiloba and Cnidium Officinale, …
17 results